Two-substrate reaction model for the heparin-catalyzed bovine antithrombin/protease reaction.
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Two-substrate reaction model for the heparin-catalyzed bovine antithrombin/protease reaction.
The kinetics of the heparin-dependent antithrombin/protease reaction were consistent with an ordered sequential two-substrate reaction model under all circumstances tested. In this model, heparin is the catalyst; while antithrombin is the first substrate and the protease is the second substrate. The first step in this reaction, the heparin-antithrombin interaction, has a KD of 25 nM but a diffu...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1983
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)33162-4